Cyrene was a small island approximately 200 miles west-southwest of Cambria. It was home to a small fishing settlement, and a unique monastery. Clerics and priests of Ioun, Erathis, and Melora cohabited in a large compound dedicated to advanced study of the planes and other locations in the universe. The monastery was established after the discovery of what appeared to be an ancient observatory.
The island was completely destroyed in 54 AU, by unknown means. No trace of magical energy could be detected, and there were no signs of battle.